SYNCOGEN: A Machine Learning Framework for Synthesizable 3D Molecular Generation Through Joint Graph and Coordinate Modeling
Introduction: The Challenge of Synthesizable Molecule Generation In modern drug discovery, generative molecular design models have greatly expanded the chemical space available to researchers, enabling rapid exploration of new compounds. Yet, a major challenge remains: many AI-generated molecules are difficult or impossible to synthesize in the laboratory, limiting their practical value in pharmaceutical and chemical development. While template-based…
